Study of red blood cells and particles in stenosed microvessels using coupled discrete and continuous forcing immersed boundary methods

A computational study of the blood flow in a stenosed microvessel is presented using coupled discrete ghost-cell and continuous-forcing immersed boundary methods. This focuses on studying platelet behaviors near stenosis with deformable red cells (RBCs). The influence varying hematocrit, area blockage, shape, driving force characteristics, RBCs, particle considered. Distinct characteristics are observed microvessels presence RBCs. motion RBCs major cause time-dependent oscillations rates, while contribution particles to fluctuations negligible. However, this effect decreases when elongated axial direction. Interestingly, as hematocrit level increases, downstream move closer vessel wall due enhanced shear-induced lift resulting from interaction among particles. Furthermore, it that geometrical changes have more significant impact profile concentration compared or force. An asymmetric leads profiles velocity distribution geometric focusing stenosis. There no change rates until blockage 0%–50%, but sudden increase root mean square occurs at an 80% blockage. contributes our understanding rheological rigid under various hemodynamic conditions.